|Application ||IHC-P, E, IP|
|Reactivity||Human, Mouse, Rat|
|Other Names||Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, PHGPx, 22.214.171.124, Glutathione peroxidase 4, GPx-4, GSHPx-4, GPX4|
|Reconstitution & Storage||Long term: -20°C; Short term: -20°C|
|Precautions||GPX4 / MCSP Antibody (clone 1H11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
|Tissue Location||Present primarily in testis.|
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Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
Esworthy R.S.,et al.Gene 144:317-318(1994).
Kelner M.J.,et al.Biochem. Biophys. Res. Commun. 249:53-55(1998).
Grimwood J.,et al.Nature 428:529-535(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Scheerer P.,et al.Biochemistry 46:9041-9049(2007).
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