|Application ||IHC-P, E, IP|
|Reactivity||Human, Mouse, Rat|
|Other Names||Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, PHGPx, 18.104.22.168, Glutathione peroxidase 4, GPx-4, GSHPx-4, GPX4|
|Reconstitution & Storage||Long term: -20°C; Short term: -20°C|
|Precautions||GPX4 / MCSP Antibody (clone 1H11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion.|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
|Tissue Location||Present primarily in testis.|
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Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
Esworthy R.S.,et al.Gene 144:317-318(1994).
Kelner M.J.,et al.Biochem. Biophys. Res. Commun. 249:53-55(1998).
Grimwood J.,et al.Nature 428:529-535(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Scheerer P.,et al.Biochemistry 46:9041-9049(2007).
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