|Application ||IHC-P, E, IP|
|Reactivity||Human, Mouse, Rat|
|Other Names||Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, PHGPx, 188.8.131.52, Glutathione peroxidase 4, GPx-4, GSHPx-4, GPX4|
|Reconstitution & Storage||Long term: -20°C; Short term: -20°C|
|Precautions||GPX4 / MCSP Antibody (clone 1H11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion.|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
|Tissue Location||Present primarily in testis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
Esworthy R.S.,et al.Gene 144:317-318(1994).
Kelner M.J.,et al.Biochem. Biophys. Res. Commun. 249:53-55(1998).
Grimwood J.,et al.Nature 428:529-535(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Scheerer P.,et al.Biochemistry 46:9041-9049(2007).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.