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CFB / Complement Factor B Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, ID |
|---|---|
| Primary Accession | P00751 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 86kDa |
| Dilution | IHC-P (1:200) |
| Gene ID | 629 |
|---|---|
| Other Names | Complement factor B, 3.4.21.47, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, BF, BFD |
| Target/Specificity | Human CFB / Factor B. In immunoelectrophoresis against human EDTA plasma a single precipitin line is obtained in the beta-2 region. The antiserum does not react with any other protein component of human serum or plasma. Cross-reactivity The antiserum ... |
| Reconstitution & Storage | Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze/thaw cycles. Store undiluted. |
| Precautions | CFB / Complement Factor B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CFB |
|---|---|
| Synonyms | BF, BFD |
| Function | Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
References
Davrinche C.,et al.Immunogenetics 32:309-312(1990).
Mejia J.E.,et al.Hum. Immunol. 39:49-53(1994).
Schwaeble W.,et al.Immunobiology 188:221-232(1993).
Horiuchi T.,et al.Mol. Immunol. 30:1587-1592(1993).
Jaatinen T.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
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