SOX17 Antibody (aa70-120)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9H6I2 |
Reactivity | Human, Mouse, Rat, Zebrafish, Monkey, Opossum, Fish |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 44kDa |
Dilution | IHC-P (5-10 µg/ml), WB (1-3 µg/ml), |
Gene ID | 64321 |
---|---|
Other Names | Transcription factor SOX-17, SOX17 |
Target/Specificity | Human SOX17 |
Reconstitution & Storage | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
Precautions | SOX17 Antibody (aa70-120) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SOX17 |
---|---|
Function | Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'- AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. |
Tissue Location | Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum. |
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Background
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity).
References
Katoh M.,et al.Int. J. Mol. Med. 9:153-157(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gimelli S.,et al.Hum. Mutat. 31:1352-1359(2010).
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