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>   home   >   Products   >   Primary Antibodies   >   HNRNPK / hnRNP K Antibody (aa200-250)   

HNRNPK / hnRNP K Antibody (aa200-250)

Rabbit Polyclonal Antibody

     
  • WB - HNRNPK / hnRNP K Antibody (aa200-250) ALS15281
    Western blot of hnRNPK in K562 cell lysate in the 1) absence and 2) presence of immunizing...
  • IHC - HNRNPK / hnRNP K Antibody (aa200-250) ALS15281
    Anti-HnRNP K antibody IHC of human adrenal.
  • IHC - HNRNPK / hnRNP K Antibody (aa200-250) ALS15281
    Anti-HnRNP K antibody IHC of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P61978
Reactivity Human, Mouse, Rat, Monkey, Opossum
Host Rabbit
Clonality Polyclonal
Calculated MW 51kDa
Dilution IHC-P (2-10 µg/ml), WB (2-5 µg/ml),
Additional Information
Gene ID 3190
Other Names Heterogeneous nuclear ribonucleoprotein K, hnRNP K, Transformation up-regulated nuclear protein, TUNP, HNRNPK, HNRPK
Target/Specificity Human HNRNPK / hnRNP K
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsHNRNPK / hnRNP K Antibody (aa200-250) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPK
Synonyms HNRPK
Function One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Cellular Location Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53- responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702)
Citations (0)

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Background

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

References

Matunis M.J.,et al.Mol. Cell. Biol. 12:164-171(1992).
Dejgaard K.,et al.J. Mol. Biol. 236:33-48(1994).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15281
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