|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IF (1:200-1:400), IHC-P (10 µg/ml), WB (1:1000-1:4000)|
|Other Names||Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28|
|Target/Specificity||Detects ~28.5kDa.Glycosylated bands ~35-50kDa.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||AQP1 / Aquaporin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Preston G.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:11110-11114(1991).
Moon C.,et al.J. Biol. Chem. 268:15772-15778(1993).
Ruiz A.C.,et al.Biochim. Biophys. Acta 1282:174-178(1996).
Li X.,et al.Biochem. Mol. Biol. Int. 32:371-377(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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