|Application ||IHC-P, E|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml),|
|Other Names||Histone-lysine N-methyltransferase 2D, Lysine N-methyltransferase 2D, 188.8.131.52, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2, KMT2D, ALR, MLL2, MLL4|
|Target/Specificity||Human MLL2. The immunizing peptide was designed from NP_003473.1. Since then the sequence has changed in the databases and currently differs at two locations in NP_003473.3.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||KMT2D / MLL2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ALR, MLL2, MLL4|
|Function||Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.|
|Tissue Location||Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver|
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Provided below are standard protocols that you may find useful for product applications.
Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
Prasad R.,et al.Oncogene 15:549-560(1997).
Scherer S.E.,et al.Nature 440:346-351(2006).
Goo Y.-H.,et al.Mol. Cell. Biol. 23:140-149(2003).
Olsen J.V.,et al.Cell 127:635-648(2006).
Mo R.,et al.J. Biol. Chem. 281:15714-15720(2006).
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