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GRIK1 / GLUR5 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - GRIK1 / GLUR5 Antibody (Internal) ALS15357
    Antibody (1 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer).
  • IHC - GRIK1 / GLUR5 Antibody (Internal) ALS15357
    Anti-GRIK1 / GLUR5 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P39086
Reactivity Human, Mouse, Rat, Monkey, Horse
Host Goat
Clonality Polyclonal
Calculated MW 104kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1:8000)
Additional Information
Gene ID 2897
Other Names Glutamate receptor ionotropic, kainate 1, GluK1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5, GRIK1, GLUR5
Target/Specificity Human GRIK1. This antibody is expected to recognise both reported isoforms according to NP_000821.1 and NP_783300.1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsGRIK1 / GLUR5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIK1
Synonyms GLUR5
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
Tissue Location Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus
Research Areas
Citations (0)

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Background

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

References

Gregor P.,et al.NeuroReport 4:1343-1346(1993).
Korczak B.,et al.Recept. Channels 3:41-49(1995).
Langer A.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Nutt S.L.,et al.NeuroReport 5:2625-2629(1994).
Shibata H.,et al.Psychiatr. Genet. 11:139-144(2001).

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$ 395.00
Cat# ALS15357
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