|Application ||WB, IHC-P, E|
|Reactivity||Human, Rat, Rabbit, Hamster, Monkey, Horse, Dog|
|Dilution||ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, 22.214.171.124, DCHT, Serine/threonine-protein kinase 39, STK39, SPAK|
|Target/Specificity||Human STK39 / SPAK.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||STK39 / SPAK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Nucleus when caspase-cleaved.|
|Tissue Location||Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis|
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May act as a mediator of stress-activated signals.
Johnston A.M.,et al.Oncogene 19:4290-4297(2000).
Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).
Melnick M.B.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Baytel D.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
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