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GLUD1/Glutamate Dehydrogenase Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - GLUD1/Glutamate Dehydrogenase Antibody (Internal) ALS15372
    GLUD1 antibody (0.3 ug/ml) staining of Mouse Liver lysate (35 ug protein/ml in RIPA buffer).
    detail
  • IHC - GLUD1/Glutamate Dehydrogenase Antibody (Internal) ALS15372
    Anti-GLUD1 antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P00367
Reactivity Human, Mouse, Monkey, Pig, Horse
Host Goat
Clonality Polyclonal
Calculated MW 61kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 2746
Other Names Glutamate dehydrogenase 1, mitochondrial, GDH 1, 1.4.1.3, GLUD1, GLUD
Target/Specificity Human GLUD1. This antibody is expected to recognize both reported isoforms (NP_005262.1; NP_036216.2).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsGLUD1/Glutamate Dehydrogenase Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLUD1
Synonyms GLUD
Function Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Cellular Location Mitochondrion. Endoplasmic reticulum. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum.
Research Areas
Citations (0)
citation

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Background

Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).

References

Nakatani Y.,et al.Biochem. Biophys. Res. Commun. 149:405-410(1987).
Amuro N.,et al.Biochem. Biophys. Res. Commun. 152:1395-1400(1988).
Nakatani Y.,et al.Nucleic Acids Res. 16:6237-6237(1988).
Mavrothalassitis G.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3494-3498(1988).
Michaelidis T.M.,et al.Genomics 16:150-160(1993).

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Discontinued
Cat# ALS15372
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