GLUD1/Glutamate Dehydrogenase Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P00367 |
Reactivity | Human, Mouse, Monkey, Pig, Horse |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 61kDa |
Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
Gene ID | 2746 |
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Other Names | Glutamate dehydrogenase 1, mitochondrial, GDH 1, 1.4.1.3, GLUD1, GLUD |
Target/Specificity | Human GLUD1. This antibody is expected to recognize both reported isoforms (NP_005262.1; NP_036216.2). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | GLUD1/Glutamate Dehydrogenase Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLUD1 |
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Synonyms | GLUD |
Function | Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). |
Cellular Location | Mitochondrion. Endoplasmic reticulum. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
References
Nakatani Y.,et al.Biochem. Biophys. Res. Commun. 149:405-410(1987).
Amuro N.,et al.Biochem. Biophys. Res. Commun. 152:1395-1400(1988).
Nakatani Y.,et al.Nucleic Acids Res. 16:6237-6237(1988).
Mavrothalassitis G.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3494-3498(1988).
Michaelidis T.M.,et al.Genomics 16:150-160(1993).
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