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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CUL2 / Cullin 2 Antibody (C-Terminus)   

CUL2 / Cullin 2 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - CUL2 / Cullin 2 Antibody (C-Terminus) ALS15379
    CUL2 antibody (1 ug/ml) staining of NIH3T3 lysate (35 ug protein/ml in RIPA buffer).
  • IHC - CUL2 / Cullin 2 Antibody (C-Terminus) ALS15379
    Anti-Cullin 2 / CUL2 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13617
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 87kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 8453
Other Names Cullin-2, CUL-2, CUL2
Target/Specificity Human CUL2 / Cullin 2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCUL2 / Cullin 2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CUL2
Function Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Research Areas
Citations (0)

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Background

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

References

Pause A.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:2156-2161(1997).
Wada H.,et al.Biochem. Biophys. Res. Commun. 257:100-105(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15379
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