|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Sentrin-specific protease 8, 126.96.36.199, Deneddylase-1, NEDD8-specific protease 1, Protease, cysteine 2, Sentrin/SUMO-specific protease SENP8, SENP8, DEN1, NEDP1, PRSC2|
|Target/Specificity||SENP8 Antibody detects endogenous levels of total SENP8 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||SENP8 Antibody (aa161-210) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DEN1, NEDP1, PRSC2|
|Function||Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.|
|Tissue Location||Broadly expressed, with highest levels in kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Mendoza H.M.,et al.J. Biol. Chem. 278:25637-25643(2003).
Gong L.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Wang Y.-G.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Wu K.,et al.J. Biol. Chem. 278:28882-28891(2003).
Gan-Erdene T.,et al.J. Biol. Chem. 278:28892-28900(2003).
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