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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNFAIP8 / SCC-S2 Antibody (aa31-80)   

TNFAIP8 / SCC-S2 Antibody (aa31-80)

Rabbit Polyclonal Antibody

     
  • IF - TNFAIP8 / SCC-S2 Antibody (aa31-80) ALS15434
    Immunofluorescence of A549 cells, using TFIP8 Antibody.
  • WB - TNFAIP8 / SCC-S2 Antibody (aa31-80) ALS15434
    Western blot of extracts from HUVEC cells, using TFIP8 Antibody.
  • IHC - TNFAIP8 / SCC-S2 Antibody (aa31-80) ALS15434
    Anti-SCC-S2 / TNFAIP8 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O95379
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 23kDa
Dilution ELISA (1:10000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 25816
Other Names Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, TNF-induced protein GG2-1, TNFAIP8
Target/Specificity TFIP8 Antibody detects endogenous levels of total TFIP8 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsTNFAIP8 / SCC-S2 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFAIP8
Function Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Cellular Location Cytoplasm.
Tissue Location Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
Volume 50 µl
Research Areas
Citations (0)

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Background

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

References

Horrevoets A.J.G.,et al.Blood 93:3418-3431(1999).
Nietfeld W.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).

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$ 395.00
Cat# ALS15434
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