|Application ||WB, IHC-P, IF, E|
|Dilution||ELISA (1:10000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, TNF-induced protein GG2-1, TNFAIP8|
|Target/Specificity||TFIP8 Antibody detects endogenous levels of total TFIP8 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||TNFAIP8 / SCC-S2 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.|
|Tissue Location||Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.|
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Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Horrevoets A.J.G.,et al.Blood 93:3418-3431(1999).
Nietfeld W.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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