|Application ||IHC-P, E|
|Dilution||ELISA (1:20000), IHC-P (5 µg/ml),|
|Other Names||Diacylglycerol kinase zeta, DAG kinase zeta, 22.214.171.124, Diglyceride kinase zeta, DGK-zeta, DGKZ, DAGK6|
|Target/Specificity||DGKZ Antibody detects endogenous levels of total DGKZ protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||DGKZ Antibody (aa601-650) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.|
|Cellular Location||Cytoplasm. Nucleus. Cell membrane.|
|Tissue Location||Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle|
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Provided below are standard protocols that you may find useful for product applications.
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.
Bunting M.,et al.J. Biol. Chem. 271:10230-10236(1996).
Ding L.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:5519-5524(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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