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DGKZ Antibody (aa601-650)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q13574 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 124kDa |
| Dilution | ELISA (1:20000), IHC-P (5 µg/ml), |
| Gene ID | 8525 |
|---|---|
| Other Names | Diacylglycerol kinase zeta, DAG kinase zeta, 2.7.1.107, Diglyceride kinase zeta, DGK-zeta, DGKZ, DAGK6 |
| Target/Specificity | DGKZ Antibody detects endogenous levels of total DGKZ protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | DGKZ Antibody (aa601-650) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DGKZ (HGNC:2857) |
|---|---|
| Synonyms | DAGK6 |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). |
| Cellular Location | Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium |
| Tissue Location | Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.
References
Bunting M.,et al.J. Biol. Chem. 271:10230-10236(1996).
Ding L.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:5519-5524(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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