TAOK1 / TAO1 Antibody (aa431-480)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q7L7X3 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 116kDa |
Dilution | ELISA (1:5000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 57551 |
---|---|
Other Names | Serine/threonine-protein kinase TAO1, 2.7.11.1, Kinase from chicken homolog B, hKFC-B, MARK Kinase, MARKK, Prostate-derived sterile 20-like kinase 2, PSK-2, PSK2, Prostate-derived STE20-like kinase 2, Thousand and one amino acid protein kinase 1, TAOK1, hTAOK1, TAOK1, KIAA1361, MAP3K16, MARKK |
Target/Specificity | TAOK1 Antibody detects endogenous levels of total TAOK1 protein. |
Reconstitution & Storage | Store at -20°C for up to one year. |
Precautions | TAOK1 / TAO1 Antibody (aa431-480) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TAOK1 |
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Synonyms | KIAA1361, MAP3K16, MARKK |
Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle |
Volume | 50 µl |
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Background
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
References
Yustein J.T.,et al.Oncogene 22:6129-6141(2003).
Jenkins S.G.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Matsuda A.,et al.Patent number WO2004058805, 15-JUL-2004.
Nagase T.,et al.DNA Res. 7:65-73(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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