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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   USP19 Antibody (aa391-440)   

USP19 Antibody (aa391-440)

Rabbit Polyclonal Antibody

     
  • WB - USP19 Antibody (aa391-440) ALS15524
    Western blot of extracts from NIH-3T3 cells, using USP19 Antibody.
  • IHC - USP19 Antibody (aa391-440) ALS15524
    Anti-KIAA0891 / USP19 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O94966
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 146kDa
Dilution ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 10869
Other Names Ubiquitin carboxyl-terminal hydrolase 19, 3.4.19.12, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19, Zinc finger MYND domain-containing protein 9, USP19, KIAA0891, ZMYND9
Target/Specificity USP19 Antibody detects endogenous levels of total USP19 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsUSP19 Antibody (aa391-440) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP19
Synonyms KIAA0891, ZMYND9
Function Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Volume 50 µl
Research Areas
Citations (0)

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Background

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.

References

Nagase T.,et al.DNA Res. 5:355-364(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Hassink G.C.,et al.EMBO Rep. 10:755-761(2009).

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$ 395.00
Cat# ALS15524
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