|Application ||IHC-P, E|
|Dilution||ELISA (1:40000), IHC-P (5 µg/ml),|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 36, 22.214.171.124, Deubiquitinating enzyme 36, Ubiquitin thioesterase 36, Ubiquitin-specific-processing protease 36, USP36, KIAA1453|
|Target/Specificity||USP36 Antibody detects endogenous levels of total USP36 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||USP36 Antibody (aa501-550) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherl A.,et al.Mol. Biol. Cell 13:4100-4109(2002).
Quesada V.,et al.Biochem. Biophys. Res. Commun. 314:54-62(2004).
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