|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||A-kinase anchor protein SPHKAP, SPHK1-interactor and AKAP domain-containing protein, Sphingosine kinase type 1-interacting protein, SPHKAP, KIAA1678, SKIP|
|Reconstitution & Storage||Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.|
|Precautions||SPHKAP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.|
|Cellular Location||Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm|
|Tissue Location||Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Lacana E.,et al.J. Biol. Chem. 277:32947-32953(2002).
Kovanich D.,et al.ChemBioChem 11:963-971(2010).
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