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>   home   >   Products   >   Primary Antibodies   >   TSHZ3 Antibody (N-Terminus)   

TSHZ3 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - TSHZ3 Antibody (N-Terminus) ALS15604
    Anti-TSHZ3 antibody IHC staining of human prostate.
  • IF - TSHZ3 Antibody (N-Terminus) ALS15604
    Immunofluorescence of TSHZ3 in mouse brain tissue with TSHZ3 antibody at 20 ug/ml.
  • WB - TSHZ3 Antibody (N-Terminus) ALS15604
    Western blot analysis of TSHZ3 in mouse brain tissue lysate with TSHZ3 antibody at 1 ug/ml in...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q63HK5
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 119kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 57616
Other Names Teashirt homolog 3, Zinc finger protein 537, TSHZ3, KIAA1474, TSH3, ZNF537
Target/Specificity Human TSHZ3.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTSHZ3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSHZ3
Synonyms KIAA1474, TSH3, ZNF537
Function Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus.
Tissue Location Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease
Citations (0)

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Background

Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

References

Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Caubit X.,et al.Development 135:3301-3310(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).

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$ 395.00
Cat# ALS15604
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