|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||GDNF-inducible zinc finger protein 1, Zinc finger and BTB domain-containing protein 23, Zinc finger protein 336, GZF1, ZBTB23, ZNF336|
|Target/Specificity||Human GZF1 / ZNF336. GZF1 antibody is human specific. At least four isoforms of GZF1 are known to exist.|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||GZF1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL|
|Tissue Location||Expressed in adult brain, heart, skeletal muscle, kidney and liver. Also detected in fetal brain and kidney, and at lower levels in fetal lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.
Fukuda N.,et al.J. Biol. Chem. 278:50386-50392(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Morinaga T.,et al.Nucleic Acids Res. 33:4191-4201(2005).
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