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>   home   >   Products   >   Primary Antibodies   >   SDHAF1 Antibody (C-Terminus)   

SDHAF1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SDHAF1 Antibody (C-Terminus) ALS15626
    Anti-SDHAF1 antibody IHC staining of human adrenal.
  • ICC - SDHAF1 Antibody (C-Terminus) ALS15626
    Immunocytochemistry of SDHAF1 in 3T3 cells with SDHAF1 antibody at 5 ug/ml.
  • IF - SDHAF1 Antibody (C-Terminus) ALS15626
    Immunofluorescence of SDHAF1 in 3T3 cells with SDHAF1 antibody at 20 ug/ml.
  • WB - SDHAF1 Antibody (C-Terminus) ALS15626
    Western blot analysis of SDHAF1 in 3T3 cell lysate with SDHAF1 antibody at (A) 1 and (B) 2 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession A6NFY7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 13kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 644096
Other Names Succinate dehydrogenase assembly factor 1, mitochondrial, SDH assembly factor 1, SDHAF1, LYR motif-containing protein 8, SDHF1
Target/Specificity Human SDHAF1. SDHAF1 antibody is predicted to not cross-react with other SDHAF protein family members.
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsSDHAF1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SDHF1
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Cellular Location Mitochondrion matrix
Tissue Location Ubiquitously expressed.
Citations (0)

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Background

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.

References

Grimwood J.,et al.Nature 428:529-535(2004).
Ghezzi D.,et al.Nat. Genet. 41:654-656(2009).
Na U.,et al.Cell Metab. 20:253-266(2014).

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$ 395.00
Cat# ALS15626
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