|Application ||WB, IHC-P, IF, ICC|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||LEM domain-containing protein 2, hLEM2, LEMD2|
|Target/Specificity||Human LEMD2. At least two isoforms of LEMD2 are known to exist; this antibody will detect only the longer isoform.|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||LEMD2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643).|
|Cellular Location||Nucleus inner membrane; Multi- pass membrane protein. Note=Lamina- associated protein residing in the inner nuclear membrane (INM) Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery|
|Tissue Location||Ubiquitously expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Involved in nuclear structure organization.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Mungall A.J.,et al.Nature 425:805-811(2003).
Brachner A.,et al.J. Cell Sci. 118:5797-5810(2005).
Olsen J.V.,et al.Cell 127:635-648(2006).
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