|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Vacuolar protein sorting-associated protein 13B, Cohen syndrome protein 1, VPS13B, CHS1, COH1, KIAA0532|
|Target/Specificity||Human VPS13B. At least five alternatively spliced transcript variants have been observed. COH1 detects two isoforms.|
|Reconstitution & Storage||Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||VPS13B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CHS1, COH1, KIAA0532|
|Function||May be involved in protein sorting in post Golgi membrane traffic.|
|Tissue Location||Widely expressed. There is apparent differential expression of different transcripts. In fetal brain, lung, liver, and kidney, two transcripts of 2 and 5 kb are identified. These transcripts are also seen in all adult tissues analyzed. A larger transcript (12-14 kb) is expressed in prostate, testis, ovary, and colon in the adult. Expression is very low in adult brain tissue. Isoform 1 and isoform 2 are expressed in brain and retina. Isoform 2 is expressed ubiquitously|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in protein sorting in post Golgi membrane traffic.
Kolehmainen J.,et al.Am. J. Hum. Genet. 72:1359-1369(2003).
Velayos-Baeza A.,et al.Genomics 84:536-549(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Nagase T.,et al.DNA Res. 5:31-39(1998).
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