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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CDKN1C / p57 Kip2 Antibody (N-Terminus)   

CDKN1C / p57 Kip2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CDKN1C / p57 Kip2 Antibody (N-Terminus) ALS15653
    Anti-CDKN1C / p57 KIP2 antibody IHC staining of human skin.
  • IF - CDKN1C / p57 Kip2 Antibody (N-Terminus) ALS15653
    Immunofluorescence of CDKN1C in 293 cells with CDKN1C antibody at 20 ug/ml.
  • WB - CDKN1C / p57 Kip2 Antibody (N-Terminus) ALS15653
    Western blot analysis of CDKN1C in 293 cell lysate with CDKN1C antibody at (A) 1 and (B) 2 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P49918
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 1028
Other Names Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2
Target/Specificity Human CDKN1C / p57 Kip2. At least three isoforms of CDKN1C are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, CDKN1C often migrates at 57kD in SDS-PAGE. CDKN1C antibody is predicted to not cross ...
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCDKN1C / p57 Kip2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDKN1C
Synonyms KIP2
Function Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
Cellular Location Nucleus.
Tissue Location Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Research Areas
Citations (0)

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Background

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.

References

Matsuoka S.,et al.Genes Dev. 9:650-662(1995).
Reid L.H.,et al.Cancer Res. 56:1214-1218(1996).
Tokino T.,et al.Hum. Genet. 97:625-631(1996).
Lam W.W.K.,et al.J. Med. Genet. 36:518-523(1999).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 395.00
Cat# ALS15653
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