|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Formin-like protein 1, CLL-associated antigen KW-13, Leukocyte formin, FMNL1, C17orf1, C17orf1B, FMNL|
|Target/Specificity||Human FMNL1. FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FMNL1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C17orf1, C17orf1B, FMNL, FRL1|
|Function||May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.|
|Cellular Location||Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).|
|Tissue Location||Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Favaro P.M.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Krackhardt A.M.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Aronsson F.C.,et al.Hum. Genet. 103:340-345(1998).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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