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SHH / Sonic Hedgehog Antibody (clone 8G3)

Mouse Monoclonal Antibody

     
  • IHC - SHH / Sonic Hedgehog Antibody (clone 8G3) ALS15710
    Anti-Sonic Hedgehog / SHH antibody IHC staining of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q15465
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8G3
Calculated MW 50kDa
Dilution ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 6469
Other Names Sonic hedgehog protein, SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein C-product, SHH
Target/Specificity Human Sonic Hedgehog / SHH
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsSHH / Sonic Hedgehog Antibody (clone 8G3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHH
Function Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).
Cellular Location Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell.
Tissue Location Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues
Volume 50 µl
Research Areas
Citations (0)

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Background

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

References

Marigo V.,et al.Genomics 28:44-51(1995).
Tate G.,et al.J. Biochem. Mol. Biol. Biophys. 4:27-34(2000).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Pepinsky R.B.,et al.J. Biol. Chem. 273:14037-14045(1998).

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$ 395.00
Cat# ALS15710
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