PNMT Antibody (clone AT1C11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P11086 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | AT1C11 |
Calculated MW | 31kDa |
Dilution | IHC-P (10 µg/ml), WB (1:500), |
Gene ID | 5409 |
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Other Names | Phenylethanolamine N-methyltransferase, PNMTase, 2.1.1.28, Noradrenaline N-methyltransferase, PNMT, PENT |
Target/Specificity | Human PNMT |
Reconstitution & Storage | Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles. |
Precautions | PNMT Antibody (clone AT1C11) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNMT |
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Synonyms | PENT |
Function | Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L- methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617). Also methylates normetanephrine (By similarity). |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Converts noradrenaline to adrenaline.
References
Kaneda N.,et al.J. Biol. Chem. 263:7672-7677(1988).
Sasaoka T.,et al.Neurochem. Int. 15:555-565(1989).
Baetge E.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3648-3652(1988).
Martin J.L.,et al.Structure 9:977-985(2001).
Gee C.L.,et al.Biochemistry 44:16875-16885(2005).
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