|Application ||WB, IHC-P, E|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:5000),|
|Other Names||Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Proapolipoprotein A-I, ProapoA-I, Truncated apolipoprotein A-I, Apolipoprotein A-I(1-242), APOA1|
|Target/Specificity||Human Apolipoprotein A1 / APOA1|
|Reconstitution & Storage||Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.|
|Precautions||APOA1 / Apolipoprotein A 1 Antibody (clone AT1E12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.|
|Tissue Location||Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.|
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Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Shoulders C.C.,et al.Nucleic Acids Res. 11:2827-2837(1983).
Cheung P.,et al.Nucleic Acids Res. 11:3703-3715(1983).
Karathanasis S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983).
Seilhamer J.J.,et al.DNA 3:309-317(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).
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