|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||Myelin transcription factor 1, MyT1, Myelin transcription factor I, MyTI, PLPB1, Proteolipid protein-binding protein, MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1|
|Target/Specificity||ZNF387 Antibody detects endogenous levels of total ZNF387 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||MYT1 Antibody (aa41-90) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0835, KIAA1050, MTF1, MYTI, PLPB1|
|Function||Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up- regulation of myelin gene transcription.|
|Tissue Location||Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.|
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Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
Nagase T.,et al.DNA Res. 5:355-364(1998).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Kim J.G.,et al.Mol. Cell. Biol. 12:5632-5639(1992).
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