|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:20000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR|
|Target/Specificity||NR1I3 Antibody detects endogenous levels of total NR1I3 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||NR1I3 / CAR Antibody (aa71-120) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.|
|Tissue Location||Predominantly expressed in liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Baes M.,et al.Mol. Cell. Biol. 14:1544-1552(1994).
Lamba J.K.,et al.J. Pharmacol. Exp. Ther. 311:811-821(2004).
Zhou G.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.