|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:20000), IHC-P (20 µg/ml), WB (1:500-1:1000)|
|Other Names||Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR|
|Target/Specificity||NR1I3 Antibody detects endogenous levels of total NR1I3 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||NR1I3 / CAR Antibody (aa71-120) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.|
|Tissue Location||Predominantly expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Baes M.,et al.Mol. Cell. Biol. 14:1544-1552(1994).
Lamba J.K.,et al.J. Pharmacol. Exp. Ther. 311:811-821(2004).
Zhou G.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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