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MOB1B / MOBKL1A Antibody (aa101-150)

Rabbit Polyclonal Antibody

     
  • IHC - MOB1B / MOBKL1A Antibody (aa101-150) ALS15761
    Human, Tonsil: Formalin-Fixed Paraffin-Embedded (FFPE)
  • WB - MOB1B / MOBKL1A Antibody (aa101-150) ALS15761
    Western blot of extracts from 293/COS7/HUVEC cells, treated with IFN 2500U/ml 30', using MOL1A...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q7L9L4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Dilution ELISA (1:40000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 92597
Other Names MOB kinase activator 1B, Mob1 homolog 1A, Mob1A, Mob1B, Mps one binder kinase activator-like 1A, MOB1B, MOB4A, MOBKL1A
Target/Specificity MOL1A Antibody detects endogenous levels of total MOL1A protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsMOB1B / MOBKL1A Antibody (aa101-150) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MOB1B
Synonyms MOB4A, MOBKL1A
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Cellular Location Cytoplasm. Nucleus
Tissue Location Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
Volume 50 µl
Research Areas
Citations (0)

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Background

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

References

Florindo C.S.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Devroe E.,et al.J. Biol. Chem. 279:24444-24451(2004).
Praskova M.,et al.Curr. Biol. 18:311-321(2008).

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$ 395.00
Cat# ALS15761
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