|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml), WB (0.2-0.6 µg/ml)|
|Other Names||Cardiolipin synthase, CLS, 2.7.8.-, Protein GCD10 homolog, CRLS1, C20orf155, CLS1|
|Target/Specificity||Human CRLS1. This antibody is expected to recognize both reported isoforms (NP_061968.1; NP_001120930.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||Cardiolipin Synthase / CRLS1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in tissues such as heart, skeletal muscle and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Houtkooper R.H.,et al.FEBS Lett. 580:3059-3064(2006).
Cheng Z.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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