|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||Origin recognition complex subunit 3, Origin recognition complex subunit Latheo, ORC3, LATHEO, ORC3L|
|Target/Specificity||Human ORC3 / ORC3L. This antibody is expected to recognize both reported isoforms (NP_862820.1 and NP_036513.2).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ORC3L / ORC3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.|
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Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Tugal T.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Dean F.B.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Pinto S.,et al.Neuron 23:45-54(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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