|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Dog|
|Dilution||ELISA (1:1000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Acidic leucine-rich nuclear phosphoprotein 32 family member B, Acidic protein rich in leucines, Putative HLA-DR-associated protein I-2, PHAPI2, Silver-stainable protein SSP29, ANP32B, APRIL, PHAPI2|
|Target/Specificity||Human ANP32B / APRIL. This antibody does NOT recognize the TNF family member also known as APRIL - Gene ID number 8741.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ANP32B / APRIL Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.|
|Cellular Location||Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase.|
|Tissue Location||Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.|
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Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
Vaesen M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Zhu L.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Mencinger M.,et al.Biochim. Biophys. Acta 1395:176-180(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
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