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ANP32B / APRIL Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q92688 |
| Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 29kDa |
| Dilution | ELISA (1:1000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 10541 |
|---|---|
| Other Names | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Acidic protein rich in leucines, Putative HLA-DR-associated protein I-2, PHAPI2, Silver-stainable protein SSP29, ANP32B, APRIL, PHAPI2 |
| Target/Specificity | Human ANP32B / APRIL. This antibody does NOT recognize the TNF family member also known as APRIL - Gene ID number 8741. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ANP32B / APRIL Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANP32B |
|---|---|
| Synonyms | APRIL, PHAPI2 |
| Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:20015864, PubMed:18039846). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:20538007, PubMed:18039846). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). |
| Cellular Location | [Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase. |
| Tissue Location | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
References
Vaesen M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Zhu L.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Mencinger M.,et al.Biochim. Biophys. Acta 1395:176-180(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
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