|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.01-0.03 µg/ml)|
|Other Names||Cofilin-2, Cofilin, muscle isoform, CFL2|
|Target/Specificity||Human CFL2. This antibody is expected to recognise both reported isoforms (NP_068733 and NP_619579)|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CFL2 / Cofilin 2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).|
|Cellular Location||Nucleus matrix. Cytoplasm, cytoskeleton. Note=Colocalizes with CSPR3 in the Z line of sarcomeres.|
|Tissue Location||Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues|
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Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Jin J.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Thirion C.,et al.Eur. J. Biochem. 268:3473-3482(2001).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2008) to UniProtKB.
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