|Application ||IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IF (1:100-1:500), IHC-P (20 µg/ml)|
|Other Names||Muscarinic acetylcholine receptor M4, CHRM4|
|Target/Specificity||CHRM4 Antibody detects endogenous levels of total CHRM4 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||CHRM4 / M4 Antibody (aa236-285) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Bonner T.I.,et al.Science 237:527-532(1987).
Bonner T.I.,et al.Neuron 1:403-410(1988).
Peralta E.G.,et al.EMBO J. 6:3923-3929(1987).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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