|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR|
|Target/Specificity||PAR1 (Cleaved-Ser42) Antibody detects endogenous levels of fragment of activated PAR1 resulting from cleavage adjacent to Ser42.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||F2R / Thrombin Receptor / PAR1 Antibody (aa23-72) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CF2R, PAR1, TR|
|Function||High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Platelets and vascular endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Vu T.-K.H.,et al.Cell 64:1057-1068(1991).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shapiro M.J.,et al.J. Biol. Chem. 271:32874-32880(1996).
Kahn M.L.,et al.J. Clin. Invest. 103:879-887(1999).
Zania P.,et al.J. Pharmacol. Exp. Ther. 328:378-389(2009).
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