|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR|
|Target/Specificity||PAR1 (Cleaved-Ser42) Antibody detects endogenous levels of fragment of activated PAR1 resulting from cleavage adjacent to Ser42.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||F2R / Thrombin Receptor / PAR1 Antibody (aa23-72) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CF2R, PAR1, TR|
|Function||High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Platelets and vascular endothelial cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Vu T.-K.H.,et al.Cell 64:1057-1068(1991).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shapiro M.J.,et al.J. Biol. Chem. 271:32874-32880(1996).
Kahn M.L.,et al.J. Clin. Invest. 103:879-887(1999).
Zania P.,et al.J. Pharmacol. Exp. Ther. 328:378-389(2009).
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