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KDM5C / Jarid1C / SMCX Antibody (C-Terminus)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | P41229 |
| Reactivity | Human, Mouse, Rat, Bovine, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 176kDa |
| Dilution | IHC-P (1:50), WB (1:1000), |
| Gene ID | 8242 |
|---|---|
| Other Names | Lysine-specific demethylase 5C, 1.14.11.-, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, KDM5C, DXS1272E, JARID1C, SMCX, XE169 |
| Target/Specificity | Human KDM5C |
| Reconstitution & Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | KDM5C / Jarid1C / SMCX Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM5C (HGNC:11114) |
|---|---|
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742} |
| Tissue Location | Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. |
| Volume | 50 µl |
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Background
Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
References
Wu J.,et al.Hum. Mol. Genet. 3:153-160(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Agulnik A.I.,et al.Hum. Mol. Genet. 3:879-884(1994).
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