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>   home   >   Products   >   Primary Antibodies   >   KDM5C / Jarid1C / SMCX Antibody (C-Terminus)   

KDM5C / Jarid1C / SMCX Antibody (C-Terminus)

Mouse Monoclonal Antibody

     
  • WB - KDM5C / Jarid1C / SMCX Antibody (C-Terminus) ALS15838
    JARID1C antibody at 1/1000 dilution Lane1: HeLa whole cell lysate 40 ug/Lane Lane2: 293 whole...
  • IF - KDM5C / Jarid1C / SMCX Antibody (C-Terminus) ALS15838
    Immunocytochemistry of HeLa cells using anti- KDM5C (C-terminus) antibody diluted 1:150.
  • IHC - KDM5C / Jarid1C / SMCX Antibody (C-Terminus) ALS15838
    Anti-KDM5C / Jarid1C / SMCX antibody IHC staining of human liver.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession P41229
Reactivity Human, Mouse, Rat, Bovine, Dog
Host Mouse
Clonality Monoclonal
Calculated MW 176kDa
Dilution IHC-P (1:50), WB (1:1000),
Additional Information
Gene ID 8242
Other Names Lysine-specific demethylase 5C, 1.14.11.-, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, KDM5C, DXS1272E, JARID1C, SMCX, XE169
Target/Specificity Human KDM5C
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsKDM5C / Jarid1C / SMCX Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM5C
Synonyms DXS1272E, JARID1C, SMCX, XE169
Function Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}
Tissue Location Expressed in all tissues examined. Highest levels found in brain and skeletal muscle
Volume 50 µl
Citations (0)

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Background

Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

References

Wu J.,et al.Hum. Mol. Genet. 3:153-160(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Agulnik A.I.,et al.Hum. Mol. Genet. 3:879-884(1994).

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$ 395.00
Cat# ALS15838
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