SPINK2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | P20155 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 9kDa |
Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml) |
Gene ID | 6691 |
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Other Names | Serine protease inhibitor Kazal-type 2, Acrosin-trypsin inhibitor, Epididymis tissue protein Li 172, HUSI-II, SPINK2 |
Target/Specificity | Human SPINK2. SPINK2 antibody is predicted to not cross-react with other SPINK family members. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | SPINK2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SPINK2 |
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Function | As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. |
Cellular Location | Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome |
Tissue Location | Expressed in epididymis (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin.
References
Moeritz A.,et al.FEBS Lett. 278:127-130(1991).
Moeritz A.,et al.Gene 123:277-281(1993).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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