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SLC35D2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, E |
|---|---|
| Primary Accession | Q76EJ3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37kDa |
| Dilution | ICC (5 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) |
| Gene ID | 11046 |
|---|---|
| Other Names | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter, Homolog of Fringe connection protein 1, HFRC1, SQV7-like protein, SQV7L, Solute carrier family 35 member D2, UDP-galactose transporter-related protein 8, UGTrel8, SLC35D2, HFRC, UGTREL8 |
| Target/Specificity | Human SLC35D2. At least two isoforms of SLC35D2 are known to exist; this antibody will recognize both isoforms. SLC35D2 antibody is predicted to not cross-react with SLC35D1 or SLC35D3. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | SLC35D2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC35D2 (HGNC:20799) |
|---|---|
| Function | Nucleotide sugar antiporter transporting UDP-N- acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the lumen of the Golgi in exchange of UMP. By supplying UDP-N-acetylglucosamine, a donor substrate to heparan sulfate synthases, probably takes part in the synthesis of these glycoconjugates. |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.
References
Suda T.,et al.J. Biol. Chem. 279:26469-26474(2004).
Ishida N.,et al.Genomics 85:106-116(2005).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Herman T.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:974-979(1999).
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