|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||MICOS complex subunit MIC27, Apolipoprotein O-like, Protein FAM121A, APOOL, CXorf33, FAM121A, MIC27|
|Target/Specificity||APOOL Antibody detects endogenous levels of total APOOL protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||APOOL / Apolipoprotein O-Like Antibody (aa219-268) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CXorf33, FAM121A, MIC27|
|Function||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).|
|Cellular Location||Mitochondrion inner membrane; Multi- pass membrane protein. Mitochondrion|
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Provided below are standard protocols that you may find useful for product applications.
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ross M.T.,et al.Nature 434:325-337(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Weber T.A.,et al.PLoS ONE 8:E63683-E63683(2013).
Pfanner N.,et al.J. Cell Biol. 204:1083-1086(2014).
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