|Application ||WB, IHC, IF, ICC, E|
|Reactivity||Human, Mouse, Rat, Monkey|
|Dilution||ELISA (1:10000), ICC (1:200-1:1000), IF (1:1000), IHC (1:100), WB (1:500-1:2000)|
|Other Names||Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, 220.127.116.11, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1|
|Target/Specificity||Human BMPR-II / BMPR2|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||BMPR2 Antibody (clone 3F6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart and liver.|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Liu F.,et al.Mol. Cell. Biol. 15:3479-3486(1995).
Rosenzweig B.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7632-7636(1995).
Nohno T.,et al.J. Biol. Chem. 270:22522-22526(1995).
Kawabata M.,et al.J. Biol. Chem. 270:5625-5630(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).
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