|Application ||WB, IHC, IF, ICC, E|
|Reactivity||Human, Mouse, Rat, Monkey|
|Dilution||ELISA (1:10000), ICC (1:200-1:1000), IF (1:1000), IHC (1:100), WB (1:500-1:2000)|
|Other Names||Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, 126.96.36.199, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1|
|Target/Specificity||Human BMPR-II / BMPR2|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||BMPR2 Antibody (clone 3F6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart and liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Liu F.,et al.Mol. Cell. Biol. 15:3479-3486(1995).
Rosenzweig B.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7632-7636(1995).
Nohno T.,et al.J. Biol. Chem. 270:22522-22526(1995).
Kawabata M.,et al.J. Biol. Chem. 270:5625-5630(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.