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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   BMPR2 Antibody (clone 3F6)   

BMPR2 Antibody (clone 3F6)

Mouse Monoclonal Antibody

     
  • IHC - BMPR2 Antibody (clone 3F6) ALS15933
    Anti-BMPR2 antibody IHC staining of human prostate.
  • WB - BMPR2 Antibody (clone 3F6) ALS15933
    Western blot using BMPR2 mouse monoclonal antibody against HeLa (1), A431 (2), NIH/3T3 (3), Cos7...
  • IF - BMPR2 Antibody (clone 3F6) ALS15933
    Immunofluorescence of Eca109 cells using BMPR2 mouse monoclonal antibody (green).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, ICC, E
Primary Accession Q13873
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 3F6
Calculated MW 115kDa
Dilution ELISA (1:10000), ICC (1:200-1:1000), IF (1:1000), IHC (1:100), WB (1:500-1:2000)
Additional Information
Gene ID 659
Other Names Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, 2.7.11.30, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1
Target/Specificity Human BMPR-II / BMPR2
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsBMPR2 Antibody (clone 3F6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMPR2
Synonyms PPH1
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in heart and liver.
Volume 50 µl
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

References

Liu F.,et al.Mol. Cell. Biol. 15:3479-3486(1995).
Rosenzweig B.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7632-7636(1995).
Nohno T.,et al.J. Biol. Chem. 270:22522-22526(1995).
Kawabata M.,et al.J. Biol. Chem. 270:5625-5630(1995).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 395.00
Cat# ALS15933
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