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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD105 Antibody (clone 8A1)   

CD105 Antibody (clone 8A1)

Mouse Monoclonal Antibody

     
  • WB - CD105 Antibody (clone 8A1) ALS15977
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ENG...
  • WB - CD105 Antibody (clone 8A1) ALS15977
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-ENG monoclonal...
  • IF - CD105 Antibody (clone 8A1) ALS15977
    Immunofluorescent staining of HeLa cells using anti-ENG mouse monoclonal antibody.
  • IHC - CD105 Antibody (clone 8A1) ALS15977
    Anti-CD105 antibody IHC staining of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P17813
Reactivity Human, Mouse, Rat, Monkey, Dog
Host Mouse
Clonality Monoclonal
Clone Names 8A1
Calculated MW 71kDa
Dilution IF (1:100), IHC-P (10 µg/ml), WB (1:200-1:4000)
Additional Information
Gene ID 2022
Other Names Endoglin, CD105, ENG, END
Target/Specificity Human CD105
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCD105 Antibody (clone 8A1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENG
Synonyms END
Function Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Endoglin is restricted to endothelial cells in all tissues except bone marrow
Volume 50 µl
Research Areas
Citations (0)

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Background

Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.

References

Bellon T.,et al.Eur. J. Immunol. 23:2340-2345(1993).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gougos A.,et al.J. Biol. Chem. 265:8361-8364(1990).
McAllister K.A.,et al.Nat. Genet. 8:345-351(1994).

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$ 395.00
Cat# ALS15977
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