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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   SPIN / SPIN1 Antibody (aa111-160)   

SPIN / SPIN1 Antibody (aa111-160)

Rabbit Polyclonal Antibody

     
  • WB - SPIN / SPIN1 Antibody (aa111-160) ALS15981
    Western blot of extracts from HeLa cells, using SPIN1 Antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y657
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 30kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 10927
Other Names Spindlin-1, Ovarian cancer-related protein, Spindlin1, SPIN1, OCR, SPIN
Target/Specificity SPIN1 Antibody detects endogenous levels of total SPIN1 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSPIN / SPIN1 Antibody (aa111-160) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPIN1
Synonyms OCR, SPIN
Function Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Cellular Location Nucleus. Nucleus, nucleolus
Tissue Location Highly expressed in ovarian cancer tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

References

Peng Y.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Zhang H.L.,et al.Chin. Sci. Bull. 45:909-914(2000).
Gao Y.,et al.Biochem. Biophys. Res. Commun. 335:343-350(2005).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15981
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