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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDK5RAP3 Antibody (aa341-390)   

CDK5RAP3 Antibody (aa341-390)

Rabbit Polyclonal Antibody

  • IHC - CDK5RAP3 Antibody (aa341-390) ALS15983
    Anti-CDK5RAP3 antibody IHC staining of human thymus.
  • WB - CDK5RAP3 Antibody (aa341-390) ALS15983
    Western blot of extracts from 293 cells, using CDK5RAP3 Antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96JB5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 80279
Other Names CDK5 regulatory subunit-associated protein 3, CDK5 activator-binding protein C53, LXXLL/leucine-zipper-containing ARF-binding protein, Protein HSF-27, CDK5RAP3, IC53, LZAP {ECO:0000303|PubMed:20164180}
Target/Specificity CDK5RAP3 Antibody detects endogenous levels of total CDK5RAP3 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCDK5RAP3 Antibody (aa341-390) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK5RAP3 (HGNC:18673)
Function Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
Cellular Location Nucleus. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes and associates with microtubules.
Tissue Location Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).
Volume 100 µl
Research Areas
Citations (0)

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Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity).


Chen J.,et al.Biochem. Biophys. Res. Commun. 294:161-166(2002).
Xie Y.H.,et al.Cell Res. 13:83-91(2003).
Favier A.-L.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Shichijo S.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 425.00
Cat# ALS15983
Availability: 5 days
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