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LMNB1 / Lamin B1 Antibody (clone 119D5-F1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, ICC, E, IHC-F, FC |
|---|---|
| Primary Accession | P20700 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Sheep, Bovine, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 119D5-F1 |
| Calculated MW | 66kDa |
| Dilution | Flo (1:100-1:200), ICC (1:100-1:200), IHC-Fr (1:50), WB (1:100-1:1000) , |
| Gene ID | 4001 |
|---|---|
| Other Names | Lamin-B1, LMNB1, LMN2, LMNB |
| Target/Specificity | Reacts with an epitope located C-terminal of residue 231 in lamin B1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | LMNB1 / Lamin B1 Antibody (clone 119D5-F1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LMNB1 |
|---|---|
| Synonyms | LMN2, LMNB |
| Function | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). |
| Cellular Location | Nucleus lamina |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
References
Pollard K.M.,et al.Mol. Cell. Biol. 10:2164-2175(1990).
Lin F.,et al.Genomics 27:230-236(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB.
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