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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PIBF1 / PIBF Antibody (C-Terminus)   

PIBF1 / PIBF Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - PIBF1 / PIBF Antibody (C-Terminus) ALS16011
    Western blot analysis of PIBF1 in human placenta tissue lysate with PIBF1 antibody at (A) 1 and...
  • IF - PIBF1 / PIBF Antibody (C-Terminus) ALS16011
    Immunofluorescence of PBIF in human spleen tissue with PBIF antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8WXW3
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 90kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 10464
Other Names Progesterone-induced-blocking factor 1, PIBF1, C13orf24, PIBF
Target/Specificity Multiple isoforms of PIBF1 exists as a result of alternative splicing event.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsPIBF1 / PIBF Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIBF1
Synonyms C13orf24, PIBF
Function Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm. Secreted. Note=In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441). Isoform 4: Secreted Note=Secreted by progesterone-treated lymphocytes (PubMed:14634107).
Tissue Location Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon (PubMed:11935316). Expressed in the first trimester pregnancy decidua (PubMed:12516630). Localized to extravillous cytotrophoblast (at protein level). Also found in syncytiotrophoblast and part of the villous cytotrophoblast Isoform 1 is expressed in first trimester and term villous trophoblast; trophoblast cells can additionally express other isoforms (PubMed:18817979). Overexpresed in solid tumors from stomach and uterus and in cells from ovary, cervical, breast, lymphoma and leukemia cancer (PubMed:25218441)
Research Areas
Citations (0)

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Background

Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

References

Rozenblum E.,et al.Hum. Genet. 110:111-121(2002).
Lachmann M.,et al.Int. J. Cancer 112:51-60(2004).
Szekeres-Bartho J.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).
Szekeres-Bartho J.,et al.Int. Immunopharmacol. 1:1037-1048(2001).

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$ 395.00
Cat# ALS16011
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