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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LPIN1 / Lipin 1 Antibody (C-Terminus)   

LPIN1 / Lipin 1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - LPIN1 / Lipin 1 Antibody (C-Terminus) ALS16028
    Western blot analysis of LPIN1 in K562 cell lysate with LPIN1 antibody at 1 ug/ml.
  • IF - LPIN1 / Lipin 1 Antibody (C-Terminus) ALS16028
    Immunofluorescence of LPIN1 in human small intestine tissue with LPIN1 antibody at 20 ug/ml.
  • IHC - LPIN1 / Lipin 1 Antibody (C-Terminus) ALS16028
    Anti-LPIN1 / Lipin 1 antibody IHC staining of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q14693
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 99kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 23175
Other Names Phosphatidate phosphatase LPIN1, 3.1.3.4, Lipin-1, LPIN1, KIAA0188
Target/Specificity LPIN1 antibody is human and mouse reactive. At least four isoforms of LPIN1 are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLPIN1 / Lipin 1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPIN1
Synonyms KIAA0188
Function Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).
Cellular Location Nucleus membrane. Cytoplasm, cytosol. Endoplasmic reticulum membrane
Tissue Location Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.
Research Areas
Citations (0)

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Background

Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).

References

Nagase T.,et al.DNA Res. 3:17-24(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Donkor J.,et al.J. Biol. Chem. 282:3450-3457(2007).

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$ 395.00
Cat# ALS16028
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