|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)|
|Other Names||Tissue factor pathway inhibitor, TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI, TFPI, LACI, TFPI1|
|Target/Specificity||TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TFPI / LACI Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.|
|Cellular Location||Isoform Alpha: Secreted.|
|Tissue Location||Mostly in endothelial cells.|
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Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Wun T.-C.,et al.J. Biol. Chem. 263:6001-6004(1988).
Girard T.J.,et al.Thromb. Res. 55:37-50(1989).
van der Logt C.P.E.,et al.Biochemistry 30:1571-1577(1991).
Girard T.J.,et al.J. Biol. Chem. 266:5036-5041(1991).
Chang J.-Y.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
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