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> home > Products > Primary Antibodies > Antibody Collections > Viral process > FBXL2 Antibody (N-Terminus)
FBXL2 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UKC9 |
| Reactivity | Human, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 47kDa |
| Dilution | ELISA (1:32000), IHC-P (10 µg/ml), WB (1:32000) |
| Gene ID | 25827 |
|---|---|
| Other Names | F-box/LRR-repeat protein 2, F-box and leucine-rich repeat protein 2 {ECO:0000312|HGNC:HGNC:13598}, F-box protein FBL2/FBL3 {ECO:0000303|PubMed:10945468, ECO:0000312|EMBL:AAF04510.1}, FBXL2 (HGNC:13598) |
| Target/Specificity | Human FBXL2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | FBXL2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXL2 {ECO:0000303|PubMed:22323446, ECO:0000312|HGNC:HGNC:13598} |
|---|---|
| Function | Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22020328, PubMed:22323446). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin- binding motifs and is thereby antagonized by calmodulin (PubMed:22020328, PubMed:22323446). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (PubMed:22020328, PubMed:22323446). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (PubMed:26037928). |
| Cellular Location | Membrane; Lipid- anchor |
| Tissue Location | Expressed in brain, heart, kidney, liver, lung, pancreas and placenta. |
Research Areas
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