|Application ||WB, IHC-P, ICC, E, Flo|
|Dilution||ELISA (1:10000), Flo (1:200-1:400), ICC (1:200-1:1000), IHC-P (1:50), WB (1:500-1:2000)|
|Other Names||Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, 18.104.22.168, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3|
|Target/Specificity||Human ALK3 / BMPR1A|
|Reconstitution & Storage||Short term +4°C; Long term -20°C|
|Precautions||ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
ten Dijke P.,et al.Oncogene 8:2879-2887(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mahlawat P.,et al.Biochemistry 51:6328-6341(2012).
Kirsch T.,et al.Nat. Struct. Biol. 7:492-496(2000).
Howe J.R.,et al.Nat. Genet. 28:184-187(2001).
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