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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2)   

ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2)

Mouse Monoclonal Antibody

     
  • IHC - ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) ALS16092
    Anti-ALK3 / BMPR1A antibody IHC staining of human skeletal muscle.
  • WB - ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) ALS16092
    Western blot using BMPR1A monoclonal antibody against HEK293 (1) and BMPR1A (AA: 179-378)-hIgGFc...
  • WB - ALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) ALS16092
    Western blot using BMPR1A mouse monoclonal antibody against PC-3 (1), K562 (2) cell lysate, and...
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E, Flo
Primary Accession P36894
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 4B7B2
Calculated MW 60kDa
Dilution ELISA (1:10000), Flo (1:200-1:400), ICC (1:200-1:1000), IHC-P (1:50), WB (1:500-1:2000)
Additional Information
Gene ID 657
Other Names Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, 2.7.11.30, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3
Target/Specificity Human ALK3 / BMPR1A
Reconstitution & Storage Short term +4°C; Long term -20°C
PrecautionsALK3 / BMPR1A Antibody (aa179-378, clone 4B7B2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMPR1A
Synonyms ACVRLK3, ALK3
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in skeletal muscle.
Volume 50 µl
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

References

ten Dijke P.,et al.Oncogene 8:2879-2887(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mahlawat P.,et al.Biochemistry 51:6328-6341(2012).
Kirsch T.,et al.Nat. Struct. Biol. 7:492-496(2000).
Howe J.R.,et al.Nat. Genet. 28:184-187(2001).

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$ 395.00
Cat# ALS16092
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